Document 0133
 DOCN  M9490133
 TI    Immunodeficiency and IL-6 production by peripheral blood monocytes in
       multicentric Castleman's disease.
 DT    9411
 AU    Ishiyama T; Nakamura S; Akimoto Y; Koike M; Tomoyasu S; Tsuruoka N;
       Murata Y; Sato T; Wakabayashi Y; Chiba S; Department of Haematology,
       Showa University School of Medicine,; Japan.
 SO    Br J Haematol. 1994 Mar;86(3):483-9. Unique Identifier : AIDSLINE
       MED/94318460
 AB    To study the pathogenesis of multicentric Castleman's disease (MCD),
       IL-6 producing cells and immune function were investigated in four MCD
       patients. The expression of IL-6 mRNA in one MCD lymph node was analysed
       by in situ hybridization. IL-6 mRNA expressing cells were scattered in
       the interfollicular areas and did not resemble plasma cells. Spontaneous
       IL-6 production was detected in the culture supernatants of peripheral
       blood mononuclear cells (PBMNC) from four patients. The IL-6 producing
       cells among the PBMNC were found to be monocytes by both in situ
       hybridization and immunohistochemistry. We evaluated immune function in
       four MCD patients. These studies show: (1) a negative PPD skin test in
       3/4 patients, (2) decreased IL-2 production in 3/4 patients, (3)
       decreased T cell colony formation in 3/4 patients, (4) decreased NK
       activity and NK cell number in 2/4 patients, (5) increased soluble IL-2
       receptor in 4/4 patients, and (6) decreased CD4/CD8 ratio in 3/4
       patients. These results show that MCD resembles, in several ways,
       acquired immunodeficiency syndrome (AIDS).
 DE    Aged  Aged, 80 and over  CD4-CD8 Ratio  Female  Giant Lymph Node
       Hyperplasia/*IMMUNOLOGY  Human  Immune Tolerance/*IMMUNOLOGY  In Situ
       Hybridization  Interleukin-1/BLOOD
       Interleukin-6/*BIOSYNTHESIS/BLOOD/GENETICS  Killer Cells,
       Natural/IMMUNOLOGY  Lymph Nodes/IMMUNOLOGY  Male  Middle Age
       Monocytes/*IMMUNOLOGY  Phytohemagglutinins/IMMUNOLOGY  Receptors,
       Interleukin-2/ANALYSIS  RNA, Messenger/ANALYSIS
       T-Lymphocytes/IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).